science + supplements

3 Supplements That Can Aid Longevity

We know that aiding longevity and life expectancy involves a variety of factors, such as our diet, exercise and other matters, but are there supplements that can aid the process and give us more options about how we age?

“Scientists believe that there are some supplements that can naturally activate our longevity genes,” Lewis Dartnell of cosmetic beauty clinic GBS Clinic 


Metformin is a medicine used to treat type 2 diabetes, and to help prevent type 2 diabetes if you’re at high risk of developing this problem as well as helping control high blood sugar, which can lead to a variety of problems such as blindness, kidney damage, sexual function and other issues.

The health benefits of Metformin are therefore by no means confined to type 2 diabetes.

One study of over 41,000 metformin users found the drug decreased frailty by 24 percent, decreased cancer risk by six percent, reduced cardiovascular disease risk by 19 percent, and increased overall lifespan by six percent.

In their concluding remarks, the study researchers wrote: “The apparent reductions in all-cause mortality and diseases of ageing associated with metformin use suggest that metformin could be extending life and health spans by acting as a neuroprotective agent.”


According to Dartnell, another supplement that may extend one’s lifespan is NMN (nicotinamide mononucleotide), which is already found in your body.

As he explained Inside the body, NMN is transformed into NAD+ – a critical coenzyme found in every cell in your body.

The body naturally produces NAD+ but levels decline as we age. Scientists have studied two such intermediates, nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), more extensively than others, and the research is encouraging. Several studies indicate that supplementing with these precursors can increase NAD+ levels and prolong the lifespan of yeast, worms, and mice.

A key study of NAD-boosting molecules (NMN) found that boosting NAD+ levels in older age can “promote health and extend lifespan”.

“NMN is thought to boost our longevity genes in a way that mimics the effects of exercise,” Dartnell reports.

In their concluding remarks, the study authors wrote: “Restoration of NAD+ levels in old or diseased animals can promote health and extend lifespan, prompting a search for safe and efficacious NAD-boosting molecules.

Resveratrol is also available in red wine

Best supplements: Resveratrol is also available in red wine (Image: Getty Images)

“Such molecules hold the promise of increasing the body’s resilience, not just to one disease, but to many, thereby extending healthy human lifespan.”


Resveratrol is a micronutrient available in supplement form and has become a popular supplement to aid longevity.

According to Dartnell, studies have shown resveratrol activates longevity genes and can slow the rate of ageing.

And it works by tricking the body into thinking it is fasting,” suggests one study.

“The good news is, resveratrol is also available in red wine, just in case you don’t fancy taking the supplements.”

According to research, determining the mechanism(s) by which resveratrol and similar molecules act, and developing methods to improve bioavailability and/or specificity, has enormous potential to benefit human health.

It is thought that resveratrol mimics fasting, said Dartnell.

As he explained, fasting is essential for switching “on” our longevity genes.

It should be noted that GBS Clinic does not sell any of these supplements and does not necessarily endorse or agree with the findings here. Dartnell just reporting on what the scientific literature has discovered.

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